e., numerous copies from the gene for cytochrome P450 isoenzyme CYP2D6 or significant morphine concentrations). These kids could possibly be notably delicate to your respiratory depressant consequences of codeine which has been rapidly metabolized to morphine. Codeine is contraindicated for submit-operative pain management in these patients (see WARNINGS – Demise Relevant to Ultra-Fast Metabolism of Codeine to Morphine and CONTRAINDICATIONS). The combination of promethazine hydrochloride and codeine phosphate need to be employed with caution in pediatric sufferers 6 many years and more mature (see WARNINGS - Use in Pediatric Sufferers).
Normally, if an opioid drugs is necessary for agony relief, opioid medicines apart from codeine are favored, as They are really more practical for many people.
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These indicators might reveal that you're an "ultra-quick metabolizer of codeine". Subsequently, there might be an excessive amount of morphine in the human body and a lot more Uncomfortable side effects from morphine than normal. Youngsters could be In particular delicate to this effect. Will not give this medicine to:
Codeine: A analyze in rats and rabbits reported no teratogenic outcome of codeine administered during the duration of organogenesis in doses starting from five to one hundred twenty mg/kg. During the rat, doses on the 120mg/ kg amount, inside the toxic assortment to the Grownup animal, have been connected with an increase in embryo resorption at some time of implantation.
Instruct nursing mothers to talk to the infant’s medical professional straight away when they discover these indicators and, if they can not reach the health care provider immediately, to go ahead and take toddler to an crisis room or get in touch with 911 (or neighborhood crisis solutions).
If this SPL has inactivated NDCs shown from the FDA initiated compliance motion, they will be specified therefore.
Sedating medication may possibly result in confusion and over-sedation while in the elderly; elderly sufferers typically really should be started on reduced doses of Promethazine Hydrochloride and Codeine Phosphate Syrup and observed closely.
Promethazine/phenylephrine/codeine may perhaps induce some laboratory assessments to provide Phony readings, which include pregnancy tests and blood sugar tests. Discuss with your Health care company When you've got any issues.
Promethazine/phenylephrine/codeine may be employed for other problems as based on your healthcare supplier.
Codeine An opioid agony reliever used to take care of gentle to moderate discomfort. It is usually combined with other medicines,which include acetaminophen, in prescription agony medicines.
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The phosphate salt of codeine occurs as white, check here needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in alcohol.
Like all opioids, codeine could potentially cause Actual physical dependence. To prevent symptoms of withdrawal, those who use codeine for some time might come to feel the necessity to utilize it daily.